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BIEGEL ET AL. Schardein, J. L., Kaump, D. H., Woosley, E. T., and Jellema, M. M. 1970 ; . Long-term toxicologic and tumorigenesis studies on an oral contraceptive agent in albino rats. Toxicol. Appl. Pharmacol. 16, 10-23. Schardein, J. L. 1980 ; . Studies of the components of an oral contraceptive agent in albino rats. I. Estrogenic component. J. Toxicol. Environ Health 6, 885-894. SchSrer, K. 1977 ; . The effects of chronic underfeeding on organ weights. How to interpret organ weight changes in cases of marked growth retardation in toxicity tests. Toxicology 7, 45-56. Sharpe, R. M., and Skakkebaek, N. E. 1993 ; . Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392-1395. Sobhon, P., and Jirasattham, C. 1974 ; . Effect of sex hormones on the thymus and lymphoid tissue of ovariectomized rats. Ada. Anat. 89, 211-225. Soto, A. M., Justicia, H., Wray, J. W., and Sonnenschein, C. 1991 ; . pNonylphenol: An estrogenic xenobiotic released from "modified" polystyrene. Environ. Health Perspect. 92, 167-173. Stimson, W. H. 1988 ; . Oestrogen and human T lymphocytes: presence of specific receptors in the T-suppressor cytotoxic subset. Scand. J. Immunol. 28, 345-350. Wade, G. N., and Gray, J. M. 1979 ; . Gonadal effects on food intake and adiposity: A metabolic hypothesis. Physiol. Behav. 22, 583--593. Wade, G. N., Gray, J. M., and Bartness, T. J. 1985 ; . Gonadal influences on adiposity. Int. J. Obesity 9, 83-92. White R. A. H., Mason D. W., Williams A. F., Galfre G., and Milstein C. 1978 ; . T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. J. Exp. Med. 148, 664-673. Yuan, Y. D. 1991 ; . Female reproductive system. In Handbook, of Toxicologic Pathology W. M. Haschek and C. G. Rousseaux, Eds. ; , pp. 891-935. Academic Press, San Diego. Zaki, K., Rizk, M , Kira, L., Nour, H., and Guirguis, R. 1979 ; . Studies on the effects of ethinyl estradiol and norethisterone acetate on the adrenal cortex and some other tissues in the rat Endokrinologie 73, 66-76.
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PartyStrands is based on a recommender or "discovery" technology called MyStrands. It is the kind of system you will find at many online music and bookstores think "Listeners also bought" at the iTunes Store ; , and at Goombah , where you can connect with people who share your passion for Air, or Air Supply. You may be able to save yourself a small fortune in cover charges by using partyStrands to peek inside nightclubs and house parties before adding them to your evening rotation. At mobile.partystrands , you can see current playlists and photos of the crowds at clubs using the service. The site displays a list of SMS users at the club, and the text messages they are posting to the communal screen inside. PartyStrands is bigger in Europe than it is in the United States. MediaStrands Inc., which developed MyStrands and partyStrands, has offices in Corvallis, Ore., and in Spain. The company said that Wonder Bar in Allston is the sole Boston-area venue using partyStrands.
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Socrates: That is correct. For instance, the discussion of what a citizen owes the laws, 32 and the love-Athens-or-leave-it speech33 that you objected to, were meant to establish the fact of an agreement between myself and the laws, so that the second principle would apply. But from the principles alone, plus a little common sense--which Crito is short on--the conclusion follows. The Speech of the Laws was just to dramatize the issues to Crito. Young Plato: I figured you had a reason for putting on the blindfold and robe, parading around with a balance-scale and clearing your throat. And it didn't affect the basic argument? Socrates: Not at all. Young Plato: So if I have this, then you say the contradiction magically vanishes if I concentrate on the following principles: 1 ; We ought not to act unjustly, even if unjustice has been done to us; 2 ; We ought to fulfill our agreements, provided that they do not enjoin any unjust action. Socrates: Right. They're a pair. They go together. Young Plato: We'll see. So it is though you had made an agreement with the Laws of Athens, to obey its legal decisions and so on. That's the first thing the Laws say to you.34 Socrates: So what can you conclude from that and 2 ; ? Young Plato: No sweat: We ought to obey the laws in all cases, provided they don't enjoin unjust actions. [Expletive deleted]! If that's all you had in mind, why didn't you just say so? Socrates: How often could I say that at my trial? I insisted that the only relevant question was to act justly and never unjustly, even if death is involved.35 I have to shout it in your ear all the time? Young Plato: I see. So it's always wrong to do wrong, whether in retaliation for an injury or an unjust action, 36 to preserve life or avert death, 37 or even in the name of justice.38 So obedience to the laws is still no justification for doing what is wrong. Socrates: Good. So now I'm off the hook. Apply the conclusion to the cases.
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JVGA, Rahman MM. The assessment ofthe amount of fat in the human body from measurements ofskinfold thickness. Br J Nutr 1967; 21: 439-44 Shwachman H, Kulezycki LL. Long term study of 105 patIents with cystic fibrosis: studies made over a five- to 14-year period. J Dis Child 1958; 96: 6-15 Weng TR, Levison H. Standards of pulmonary function in children. Rev Bespir Dis 1969; 99.879-94 Torshen KP, Kroeker LI Pcterson RA. Self-concept assessment for young children: development ofa self-report, peer comparison measure. Contemp Educ Psych 1977 2: 325-31 Jensen JM, Michael JJ, Michael WB. The concurrent validity of the primary self-concept scale for a sample of third grade children. Educ Psych Meas 1975; 35: 1011-16 Hughes HM. Measures of self-concept and self-esteem for children ages 3-12 years: a review and recommendations. Clin Psychol Rev 1984; 4: 657-92 Mintz R, Muller D. Academic achievement as a function of specific and global measures ofself-eoncept. J Psychol 1977; 97.
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Given are the mean + SE of baseline values and levels after 3 months of estrogen use for levels of lipoprotein-related constituents relative to lipoprotein cholesterol, by weight. The percent change in mean absolute levels and P values for the change are also given and aranesp.
Florida Panther Research 7500 ; Florida Panther Genetic Restoration and Management 7508 ; July 1997 - June 1998 July 1995 - June 2001 Darrell Land, Bureau of Wildlife Diversity Conservation, Florida Game and Fresh Water Fish Commission, 566 Commercial Blvd., Naples, FL 34104-4709 Sharon K. Taylor, DVM, Bureau of Wildlife Diversity Conservation, Florida Game and Fresh Water Fish Commission, 566 Commercial Blvd., Naples, FL 341044709 Mark Lotz, Bureau of Wildlife Diversity Conservation, Florida Game and Fresh Water Fish Commission, 566 Commercial Blvd., Naples, FL 34104-4709.
Capillary wedge pressure PCWP ; . Mean pressures were derived by electronic integration. An integrated bedside computer Edwards Model 9520 ; and 10 ml of cold 5% dextrose injectate were used for thermodilution measurements of cardiac output CO ; . Determinations of CO were performed at least three times until less than 10% variation in consecutive values was obtained. Standard formulas used to calculate derived measurements were as follows: Systemic vascular resistance SVR, dynes-sec-cm- 5 ; [ MBP - mean CVP ; CO] x 80 Cardiac index CI, liters min m2 ; CO body surface area Stroke volume index SVI, mlUm2 ; Cl heart rate Left ventricular stroke work index SWI, g-m m2 ; [SVI x MBP - mean PCWP ; ] x 0.0136 Hemodynamic data were obtained on the third day of placebo while patients were resting in the supine position with feet elevated 30 cm in bicycle position ; and after each 3 min exercise stage as well as immediately before the cessation of exercise. Repeat rest and exercise hemodynamic measurements were obtained after 24 hr and 60 hr of cibenzoline therapy in an identical manner and workload as during placebo. The initial cibenzoline loading dose was 260 mg orally followed by 130 mg orally twice daily during the 3 day hemodynamic study. Because two of the first 10 patients experienced severe hemodynamic deterioration during the first 3 days, the loading dose was reduced to 160 mg for the remaining eight patients. Maintenance dosing during the remainder of the inpatient portion of the trial was 130 mg orally twice daily, which was increased to 160 mg orally twice daily if a 75% or greater reduction in runs of VT had not been achieved. After the right heart catheter was removed, patients were returned to the General Clinical Research Center. Before hospital discharge, 48 hr of continuous ambulatory ECG recordings were obtained to evaluate antiarrhythmic effect. Efficacy was defined by ambulatory ECG recordings and required a 75% or greater reduction in runs of VT day when compared with the placebo ambulatory electrocardiograms. Electrophysiologic study was not used to determine antiarrhythmic efficacy. The drug was discontinued before discharge if there was lack of antiarrhythmic efficacy sustained VT or the failure to achieve a 75% or greater reduction in runs of nonsus and aredia.
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I: Physical training group supervised bicycle ergometer training 3 x 50 mins wk C: No intervention * Data from `borderline hypertensive` strata are reported. I: aerobic exercise regime walking, jogging, stationary bicycling, heart rate 65-80% of max. C: placebo exercise regime -stretching, easy calisthenics, heart rate 60% of max. * Both interventions were 30 minutes, 4 times weekly 2 unsupervised and 2 supervised sessions.
On Apri 6-7, 2003, The Daniella Maria Arturi Foundation and the Diamond Blackfan Anemia Foundation, Inc "DBAF" ; cosponsored the Diamond Blackfan Anemia International Consensus Conference. The conference was held in New York City. The Mission of the Diamond Blackfan Anemia International Consensus Conference is to increase the understanding of Diamond Blackfan Anemia by fostering an international collaboration to continue to investigate the pathophysiology and genetics of Diamond Blackfan Anemia DBA ; as well as update current treatment options and review potential new treatment alternatives. This forum is dedicated to establishing a research agenda and fostering international collaborations in DBA. This research will enhance the understanding of DBA with the ultimate goal of providing a cure for DBA patients around the globe. World renowned scientists from many different countries attended. Scientists and physicians presenting at the conference included Elizabeth Kang, Blanche Alter, Jan Abkowitz, Thierry LeBlanc, Joerg Meerphol, Jeffrey Lipton, Steven Spandorfer, Marcus Hughes, Gilbert Tchernia, Leonard Zon, Jason Fixler, Mohandas Narla, Hanna Gazda, Johan Richter, Han Matsson, Sujit Sheth, Joel Anne Chasis, Steve Arkin, Yasar Celiker, Sarah Ball, Stefan Karlsson, and Pankaj Qasba. Those attending presented updates on their current research. The results presented were very encouraging. Progress is being made. The following is a summary of some of the topics covered during the conference: a. Clinical update and new projects The NIH continues to conduct clinical trials involving the use of ATG and Cyclosporine in combination for the treatment of DBA. To date, 13 patients have been treated and all patients tolerated the treatment well. Two patients became transfusion independent and are currently being tapered off Cyclosporine. The third patient had a complete response while ten patients showed no response. NIH is also investigating gene therapy based treatments and a new stem cell transplant conditioning regiment. The National Cancer Institute is continuing its study of cancer susceptibility within families affected by inherited bone marrow failure syndromes. Researchers continue to experiment with the use of Metoclopramide in patients with DBA. A pilot study was completed with 15 transfusion or steroid dependent patients. Three persons discontinued therapy and three were noncompliant. Of the nine patients that completed the trial, three responded. A larger study is now being initiated with DBA patients. In addition, as discussed elsewhere in this newsletter, similar research is also being conducted and sponsored by the DBAF ; in France. Several presentations were given on stem cell transplants of DBA patients. In Germany for instance, 18 DBA patients received stem cell transplants. Seventeen of the patients are alive with median follow-up of 6.4 years. In the U.S., the Diamond Blackfan Anemia Registry reports 27 DBA transplant patients. The survival rate for HLA matched siblings versus alternative donor transplant was 80% versus 20%; demonstrating that alternative donor transplants must be approached cautiously. b. Pre-Implantation Genetic Diagnosis PGD ; and its implications PGD combines the technologies of invitro fertilization, embryo culture and biopsy, and single cell molecular genetics, to provide couples at high genetic risk the opportunity to begin their pregnancy with the knowledge that their fetus will not have the inherited disorder that afflicts their family. Since the genes that may be principle cause for DBA are not yet completely understood, PGD is not recommended for couples who wish to have complete certainty that their child will not have DBA. However, PGD is viable for couples wishing to have a child that will be a matched HLA donor for another sibling with DBA. c. In Vivo Model Systems for the study of DBA Zebra fish is a powerful genetic and developmental system for understanding Hematopoiesis in congenital blood disorders. The conference included a discussion of the techniques and studies being done with the use of Zebra fish to better understand DBA. In addition, researchers are experimenting with fruit flies in order to understand the role of RPS 19 in DBA. The conference included a discussion of the fruit fly as a potential model for DBA. d. Gene Therapy and Gene Discovery Several presentations were made updating the participants on the various studies Continued on Page 6 ; 3 and arixtra.
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The 2007 Community Awards recipients were announced today by the Calistoga Chamber of Commerce Board of Directors. They are Citizen of the Year Shari Hanson, Business of the Year shared award ; : Calistoga Spa Hot Springs & Dr. Wilkinson's Hot Springs Resort and the Gary Barrett Lifetime Achievement Award to Diane Barrett. In addition, the Napa County Child Care Planning Council will be presenting an award for one of the most Family Friendly Businesses to SpaEquip Incorporated, the first Calistoga business to receive this award. The annual event honors those people and businesses who have made significant contributions to the Calistoga community in the past year through their work, their example of leadership and their support of organizations and events which enrich the entire community. Business of the Year is being shared for the first time since both businesses were found to equally worthy of the honor. The event will also mark the installation of new Chamber Board Chair Bob Beck, of Beck & Taylor Realty, and Vice Chair Ric Pielstick, of the Chanric Inn. Will Durst, one of the nation's foremost political comics, is the headlining entertainer for the evening, bringing his distinctly funny and astute take on the state of American politics. The San Franciscobased Durst has been described as "quite possibly the best political satirist working in the country today" by The New York Times, and London's The Independent calls him "an urbane guerilla with a keen eye for the ridiculous." Bob Fellion will serve as auctioneer for the event, which will feature auction lots with vacation trips, wine and other special items donated by local businesses. Got Your Tickets? Call 942-6333 and apri.
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