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A 0.7-mm-thick pin made of hardened stainless steel was inserted intramedullary for 199 rats through the proximal right tibia distally to the tibiofibular junction just proximally to the ankle joint through a small skin incision, which was then closed with two sutures. The prenailed tibiofibular bone was manually fractured against a metal edge, method modified from Greiff 1978 ; at exactly 24 millimetres from the calcaneus from both sides, so that the periost was also broken. The fracture was located 2-3 millimetres proximal to the tibiofibular junction, and both the tibia and the fibula were fractured. The final x-rays showed that the fibulas were intact in three animals 1 in group 1, in group 3 and 1 in group 4 ; . These were, however, included in the analysis because we think that the intact fibula did not have a predominant fixation effect on the intramedullary steel pin. Bubrenorphine Temgesic, Reckitt & Colman, Hull, UK ; was given as a s.c. dose of 0.45 mg kg for postoperative analgesia. The pin stabilised the tibia enough to allow full weight bearing immediately after the operation, i.e. the animal could walk freely. Thereafter, further administration was continued for 4 weeks in groups 1, 3 and 5 and for 8 weeks in groups 2, 4 and 6. Clinical parameters of the study population are summarized in Tab. 1. In all subjects, both with periodontitis and healthy ones, smoking status was classified as current smoker, non-smoker never smoke ; , and former smoker.
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