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From the Laboratory for Cerebrovascular Biophysics, Neurosurgical Service, Massachusetts General Hospital and the Department of Surgery, Harvard Medical School, Boston, Massachusetts. Supported by National Heart, Lung, and Blood Institute Grant HL22573 to N.T.Z. ; . Address for reprints: Nicholas T. Zervas, MD, Massachusetts General Hospital, Neurosurgical Service, Boston, MA 02114. Received April 17, 1989; accepted August 1, 1989.
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Vol. 295 Chromatopac C-R1A; Shimadzu Co. ; under the following conditions: column, Zorbax ODS 4.6-mm inside diameter 150 mm DuPont, Wilmington, DE ; for both drugs; mobile phase, 50 mM acetate buffer pH 4.0 ; in acetonitrile at 19: 1 for acetazolamide, 10 mM sodium acetate in methanol at 2: 1 for furosemide; flow rate, 1.0 ml min for acetazolamide, 0.8 ml min for furosemide; wavelength, 254 nm for acetazolamide, 280 nm for furosemide; and temperature, 40C for both agents. Statistical Analysis. Data were analyzed statistically with ANOVA, followed by Fisher's t test for multiple comparisons.
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Table 3 Adverse Events in the Anaplastic Astrocytoma Trial in Adults 5% ; No. % ; of TEMODAR Patients N 158 ; All Events Grade 3 4 Any Adverse Event 153 97 ; 79 50 ; Body as a Whole Headache 65 41 ; 10 Fatigue 54 34 ; 7 Asthenia 20 13 ; 9 Fever 21 13 ; 3 Back pain 12 8 ; 4 Cardiovascular Edema peripheral 17 11 ; 1 Central and Peripheral Nervous System 8 5 ; 36 Convulsions 10 6 ; 29 Hemiparesis 1 ; 19 Dizziness 2 1 ; 17 Coordination abnormal 6 4 ; 16 Amnesia 0 16 10 ; Insomnia 1 ; 15 Paresthesia 5 3 ; 15 Somnolence 4 3 ; 13 Paresis 3 2 ; 13 Urinary incontinence 3 2 ; 12 Ataxia 1 ; 11 Dysphasia 0 9 6 ; Convulsions local 1 ; 9 Gait abnormal 0 8 5 ; Confusion Endocrine Adrenal hypercorticism 13 8 ; 0 Gastrointestinal System Nausea 84 53 ; 16 Vomiting 66 42 ; 10 Constipation 52 33 ; 1 Diarrhea 25 16 ; 3 Abdominal pain 14 9 ; 2 Anorexia 14 9 ; 1 Metabolic Weight increase 8 5 ; 0 and tenex.
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1. Kronenberg F, Fugh-Berman A 2002 Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 137: 805 813 Tamir S, Eizenberg M, Somjen D, Izrael S, Vaya J 2001 Estrogen-like activity and tenofovir.
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Williams, David A R ed ; 1997 ; Environmental and Resource Management Law in New Zealand, p. 40-41. 388 This seems to be a difference from the understanding of aboriginal title in the Canadian law, where all land and natural resource uses in principle are allowed. Compare with subsection 6.4.6. However, it should be noted that the understanding of Maori customary title is not well established in the New Zealand law. 389 Graham, Sir Douglas 2001 ; The Legal Reality of Customary Rights for Maori, pp. 6 & 9. A customary title is quite unlike "normal" property rights to land for instance fee simple title ; , where the owner may be absent for years. 390 Williams, David A R ed ; 1997 ; Environmental and Resource Management Law in New Zealand, pp. 40-41. 391 Graham, Sir Douglas 2001 ; The Legal Reality of Customary Rights for Maori, p. 19. 392 Te Runanganui o Te Ika Whenua Inc Society v. Attorney-General [1994] 2 NZLR 20, p. 26.
Tation in experimental animals of the parallel his togenesis of the melanoma of the human and ex penimental animal, although the original descnip tion of the Handing and Passey mouse melanoma suggests a similar genesis 10 ; . Neither the histo genesis nor the morphology of the original Cloud man mouse melanoma 591, on of the primary melanotic lesion observed by Strong in mice painted with methylcholanthnene appears to have been recorded 1 1 ; . Moreover, with the exception of one feature, the histologic appearance of the malignant mela nomas of hamsters corresponds well with that of and terfenadine.
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Objective--Chronic renal failure CRF ; is associated with a 10- to 20-fold increase in cardiovascular risk. Vascular calcification is a prominent feature of cardiovascular disease in patients with end-stage renal failure and contributes to the excess mortality in this population. In this study, we explored in vivo X-ray microtomography micro-CT ; as a tool to detect and follow-up vascular calcifications in the aorta of living rats with adenine-induced CRF. Methods and Results--With in vivo micro-CT, calcification of the aorta in uremic rats was clearly discernible on transversal virtual cross-sections. Micro-CT findings correlated well with tissue calcium content and histology. Repetitive scans in animals with light, moderate, and severe vascular calcification showed good reproducibility with minimal interference of motion artifacts. Moreover, both calcified volume and area could be quantified with this method. Conclusions--In vivo micro-CT scanning is a sensitive method to detect vascular calcifications in CRF rats, allowing follow-up and quantification of the development, and potential reversal during treatment, of vascular calcifications in living animals. Arterioscler Thromb Vasc Biol. 2006; 26: 2110-2116. ; Key Words: ectopic calcification imaging micro-CT renal failure kidney and temodar.
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