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1 Dept. of Nephrology, University of Antwerp, Belgium; 2Dept. of Nephrology, Clinical Centre Skopje, Macedonia; 3Manchester Royal Infirmary, Manchester; 4Musculo-skeletal Research Group, Manchester, UK; 5Dept. of Medicine, Charles University, Prague, Czech Republic; 6E13 Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa; 7Clinical Centre of Serbia, Institute of Urology and Nephrology, Belgrade, Yugoslavia; 8UOD Centro di Nefrologia e Dialisi, Ospedale S Giovanni in Laterano, Roma; Servizio di Nefrologia Renale Ipertensione Arteriosa, Universita La Sapienza, Roma, Italy; 10Dept. of Nephrology, Cracow, Poland; 11Fresenius Medical Care, Vila Franca de Xira, Portugal; 12Servicio de Nefrologia Hospital, Universitario de Canarias, Tenerife; 13 Institute for Internal Diseases, Novi Sad; 14Clinic of Rheumatology and Clinical Immunology, VMA, Belgrade; 15Centre for Renal Diseases, Zvezdara University Hospital, Belgrade, Yugoslavia.

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Recipient age and diastolic blood pressure were included as independent predictors of RI R 0.57, P 0.0001 ; . Even though RI was not different between patients receiving CsA and patients treated with tacrolimus or without anticalcineurin drugs 0.700.08, 0.710.07 and 0.740.11, respectively, P NS ; , we observed a negative correlation between CsA whole blood levels at the time of biopsy and RI R 0.27, P 0.04 ; . This association was not observed in patients receiving tacrolimus. Accordingly, the univariate and multivariate analysis was repeated in the 58 patients receiving CsA. In this subset of patients, recipient age R 0.59, P 0.0001 ; and diastolic blood pressure R 0.36, P 0.005 ; were also correlated with RI. However, in the multivariate analysis, only recipient age and CsA whole blood level at the time of biopsy were independent predictors of RI R 0.64, P 0.0001 ; . Histological parameters and resistive index RI was not different according to histological diagnosis Table 4 ; . Glomerulitis was the only histological lesion evaluated according to Banff criteria that was associated with RI Figure 2 ; . There was no correlation between RI and Vg, Vvinterstitium cortex or Vvintima artery. Since glomerulitis was evaluated according to an ordinal scale, the intra-observer variability in the.
The disease severity of all of the accessions was among 2.1 to 10, showing obvious difference in resistant levels to verticillium wilt among S. melongena and its affinities. However, no accession was demonstrated as completely resistance, i.e. average interaction phenotype scored less than 1.0. Table 1 lists the 10 accessions identified with the lowest disease severity. II6B030 1, II6B0506, II6B0980, II6b0345, had the lowest disease severity scores of 2.1, 2.4, 2.7 and 3.0 respectively. These 4 accessions had also highest percentage of resistant plants of4l.9, 31.0, 28.1., and 29.0 respectiyely. Some accessions had a few individuals of disease free or with an interaction phenotype score of 1.0. Among the total 1013 accessions screened 20 accessions did not contain any living plant while 15 accessions had more than 10 or more resistant plants. Generally speaking, wild species and semi-wild species demonstrated higher resistance to verticillium wilt. But it is noted that some wild affinities of eggplant also showing a high disease severity Table 2 and velcade.

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Ohno, K., Araki, N., Yanase, T., Nawata, H., and Iida, M. 2004 ; . A novel nonradioactive method for measuring aromatase activity using a human ovarian granulosa-like tumor cell line and an estrone ELISA. Toxicol Sci 82, 443-50. Ohno, S., Shinoda, S., Toyoshima, S., Nakazawa, H., Makino, T., and Nakajin, S. 2002 ; . Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. J Steroid Biochem Mol Biol 80, 355-63. Ostby, J., Kelce, W. R., Lambright, C., Wolf, C. J., Mann, P., and Gray, L. E., Jr. 1999 ; . The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro. Toxicol Ind Health 15, 80-93. Parker, K. L., and Schimmer, B. P. 1995 ; . Transcriptional regulation of the genes encoding the cytochrome P-450 steroid hydroxylases. Vitamins and Hormones 51, 339-370. Pascoe, L., Jeunemaitre, X., Lebrethon, M. C., Curnow, K. M., Gomez-Sanchez, C. E., Gasc, J. M., Saez, J. M., and Corvol, P. 1995 ; . Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree. J Clin Invest 96, 2236-46. Pinter, A., Torok, G., Borzsonyi, M., Surjan, A., Calk, M., Kelecsenvi, Z., and Kocsis, Z. 1990 ; . Long-term carcinogenicity bioassay of the herbicide atrazine in F344 rats. Neoplasma 37, 533-544. Rainey, W. E. 1999 ; . Adrenal zonation: clues from 11[beta]-hydroxylase and aldosterone synthase. Molecular and Cellular Endocrinology 151, Rainey, W. E., Bird, I. M., and Mason, J. I. 1994 ; . The NCI-H295 cell line: a pluripotent model for human adrenocortical studies. Mol Cell Endocrinol 100, 45-50. Rainey, W. E., Bird, I. M., Sawetawan, C., Hanley, N. A., McCarthy, J. L., McGee, E. A., Wester, R., and Mason, J. I. 1993 ; . Regulation of human adrenal carcinoma cell NCIH295 ; production of C19 steroids. J Clin Endocrinol Metab 77, 731-7. Reeder, A. L., Foley, G. L., Nichols, D. K., Hansen, L. G., Wikoff, B., Faeh, S., Eisold, J., Wheeler, M. B., Warner, R., Murphy, J. E., and Beasley, V. R. 1998 ; . Forms and prevalence of intersexuality and effects of environmental contaminants on sexuality in cricket frogs Acris crepitans ; . Environ Health Perspect 106, 261-6. Reincke, M., Beuschlein, F., Menig, G., Hofmockel, G., Arlt, W., Lehmann, R., Karl, M., and Allolio, B. 1998 ; . Localization and expression of adrenocorticotropic hormone receptor mRNA in normal and neoplastic human adrenal cortex. J Endocrinol 156, 415-23. Roberge, M., Hakk, H., and Larsen, G. 2004 ; . Atrazine is a competitive inhibitor of phosphodiesterase but does not affect the estrogen receptor. Toxicol Lett 154, 61-8. Rosselli, M., Reinhart, K., Imthurn, B., Keller, P. J., and Dubey, R. K. 2000 ; . Cellular and biochemical mechanisms by which environmental oestrogens influence reproductive function. Hum Reprod Update 6, 332-50. Sanderson, J. T., Boerma, J., Lansbergen, G. W., and van den Berg, M. 2002 ; . Induction and inhibition of aromatase CYP19 ; activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol 182, 44-54. Sanderson, J. T., Hordijk, J., Denison, M. S., Springsteel, M. F., Nantz, M. H., and Van Den Berg, M. 2004 ; . Induction and Inhibition of aromatase CYP19 ; activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci 82, 70-79. Sanderson, J. T., Letcher, R. J., Heneweer, M., Giesy, J. P., and van den Berg, M. 2001a ; . Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect 109, 1027-31. page 39.

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FIG. 1. Panel A, karyotype [46XY, t 9; 22 ; q34; q11 ; ] of a patient with Philadelphia-positive CML 1 derivative chromosome 9 arrow ; 2 Philadelphia chromosome arrow ; 3 ; . As result of the translocation, the q long ; arm of chromosome 22 appears shortened and this chromosome was originally referred to as 22q-. FISH 4 ; . As result of the t 9; 22 ; , the BCR green signal ; and ABL genes red signal ; are juxtaposed and form a yellow fusion signal. Panel B, schematic illustration of the Philadelphia translocation. The ABL and BCR genes reside on the long arms of chromosomes 9 and 22, respectively. As a result of the translocation, an ABL-BCR chimeric gene is formed on the derivative chromosome 9 and a BCR-ABL gene on the derivative chromosome 22 Philadelphia chromosome ; . Hatched areas, centromeric region and vfend.

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